Plasma ProANP ₁–₃₀ Reflects Salt Sensitivity in Subjects With Heredity for Hypertension
Why the study?
Does plasma proANP(1-30) correlate with salt sensitivity in healthy subjects with heredity for hypertension?
Population
30 healthy subjects with heredity for hypertension
Comparison
High-salt diet (240 mmol/d) for 1 week vs Low-salt diet (10 mmol/d) for 1 week and baseline
Design
Cohort
Follow-up
2 weeks
Authors
Discussion
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Member takes
Implication
ProANP(1-30) may identify salt-sensitive individuals; hypothesis-generating for biomarker-guided salt restriction in hypertension-prone subjects.
Structured PICO
Does plasma proANP(1-30) correlate with salt sensitivity in healthy subjects with heredity for hypertension?
P
Population
30 healthy subjects with heredity for hypertension
I
Intervention
High-salt diet (240 mmol/d) for 1 week
C
Comparator
Low-salt diet (10 mmol/d) for 1 week and baseline
O
Outcome
Correlation of plasma proANP(1-30) and urinary urodilatin with salt sensitivity (difference in mean arterial blood pressure between high and low salt diets)surrogate
Plasma proANP(1-30) closely correlates with salt sensitivity and may serve as a biomarker to identify individuals who would benefit from dietary salt restriction to prevent hypertension.
Cite This Study
Melander et al. (2002) studied this question.