What question did this study set out to answer?

Evaluate plasma atrial natriuretic peptide (ANP) behavior at rest and during upright posture in young men with essential hypertension and in normotensive individuals with a family history of the disease.

October 1, 1990American Journal of Hypertension

Plasma Atrial Natriuretic Peptide in Young Normotensive Subjects With a Family History of Hypertension and in Young Hypertensive Patients

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Why the study?

Are plasma ANP levels elevated in young essential hypertensives and normotensives with a family history of hypertension compared to controls?

Population

67 men on normal sodium intake, comprising 26 untreated essential hypertensives, 21 normotensives, and 20…

Comparison

Essential hypertension or normotension with… vs Normotensive controls without hypertensive…

Design

Cross-sectional

Authors

ASAnna SantucciUniversity of Rome Tor Vergata CFClaudio FerriPreventive Cardiology ICI CammarellaIRCCS San Camillo Hospital

Discussion

Member takes

Implication

May signal early ANP changes in hypertension; leaves open causal role and biomarker utility pending prospective data.

Key Points

Evaluate plasma atrial natriuretic peptide (ANP) behavior at rest and during upright posture in young men with essential hypertension and in normotensive individuals with a family history of the disease.
Evaluated 26 untreated essential hypertensive men, 20 normotensive men with hypertensive heredity, and 21 normotensive controls (mean age 22.1 ± 1.9 years) maintained on a standard sodium diet (120 mEq Na+/day).
Measured plasma ANP concentrations using radioimmunoassay from blood drawn in a supine position upon waking and again following 1 hour of orthostatism.
Hypertensive subjects exhibited higher plasma ANP levels (supine: 44.5 ± 19.4 pg/mL; orthostatism: 24.1 ± 11.6 pg/mL) than normotensive controls (supine: 38.3 ± 19.4 pg/mL; orthostatism: 19.9 ± 10.6 pg/mL).
Normotensive subjects with hypertensive heredity showed intermediate ANP levels (supine: 42.1 ± 16.8 pg/mL; orthostatism: 23.2 ± 10.8 pg/mL), representing an increase of +9% supine and +14.2% during orthostatism compared to controls.

Structured PICO

Are plasma ANP levels elevated in young essential hypertensives and normotensives with a family history of hypertension compared to controls?

Population

67 men (mean age 22.1 +/- 1.9 years) on normal sodium intake (120 mEq of Na+/day), comprising 26 untreated essential hypertensives, 21 normotensives, and 20 normotensives with hypertensive heredity.

Intervention

Essential hypertension or normotension with hypertensive heredity

Comparator

Normotensive controls without hypertensive heredity

Outcome

Plasma atrial natriuretic peptide (ANP) levels evaluated by radioimmunoassay in supine position upon waking and after 1 h of orthostatismsurrogate

Plasma ANP levels are elevated in young men with essential hypertension and slightly elevated in normotensive men with a family history of hypertension.

Cite This Study

Santucci et al. (1990) studied this question.

synapsesocial.com/papers/6a8839bcd03e68c3c9a54695 https://doi.org/10.1093/ajh/3.10.782

Topics

Hypertension management

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Plasma Atrial Natriuretic Peptide in Young Normotensive Subjects With a Family History of Hypertension and in Young Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Plasma Atrial Natriuretic Peptide in Young Normotensive Subjects With a Family History of Hypertension and in Young Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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