Key result
Adult rat alveolar epithelial cells express multiple voltage-gated K+ channel subunits localized to the apical membrane, explaining the observed variability in inactivation gating and K+ selectivity.
Adult rat alveolar epithelial cells express multiple subtypes of voltage-gated K+ channels on their apical membrane, which may contribute to basal K+ secretion.
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Should not alter clinical lung fluid management; leaves open the role of apical Kv subunits in human alveolar K+ secretion.
Lee et al. (2003) studied this question. Adult rat alveolar epithelial cells express multiple voltage-gated K+ channel subunits localized to the apical membrane, explaining the observed variability in inactivation gating and K+ selectivity.
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