Key result
Rat prorenin and renin bound to the recombinant rat renin/prorenin receptor with Kd values of 8.0 and 20 nM, respectively, and expressed enzymatic activity in vitro.
Population
Recombinant rat renin/prorenin receptor prepared from the cytoplasmic fraction of insect cells using a…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open the receptor's in vivo relevance and need for human translational studies.
Rat prorenin and renin bind to the recombinant renin/prorenin receptor and retain enzymatic activity in vitro, providing a model for studying renin-angiotensin system receptor interactions.
Nabi et al. (2006) studied this question. Rat prorenin and renin was evaluated on Binding affinity (Kd) to recombinant rat renin/prorenin receptor. Rat prorenin and renin bound to the recombinant rat renin/prorenin receptor with Kd values of 8.0 and 20 nM, respectively, and expressed enzymatic activity in vitro.
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