Key result
Short-term dietary sodium restriction and acute salt loading decreased plasma marinobufagenin levels in salt-sensitive hypertensive patients, in contrast to salt-insensitive patients.
Why the study?
Increased marinobufagenin (MBG) synthesis has been suggested in response to high dietary salt intake, but the effects of short-term changes in sodium intake on plasma MBG levels in primary salt-sensitive versus salt-insensitive hypertension required determination.
Do short-term changes in sodium intake alter plasma marinobufagenin levels in patients with primary salt-sensitive and salt-insensitive hypertension?
Do short-term changes in sodium intake alter plasma marinobufagenin levels in patients with primary salt-sensitive and salt-insensitive hypertension?
Decreased marinobufagenin secretion in response to acute salt loading may play an important role in the pathogenesis of salt sensitivity in hypertensive patients.
Answers are grounded in this paper and cite their sources.
Sodium restriction was associated with lower MBG in salt-sensitive hypertension; leaves open its role in salt sensitivity and need for prospective validation.
Increased marinobufagenin (MBG) synthesis has been suggested in response to high dietary salt intake. The aim of this study was to determine the effects of short-term changes in sodium intake on plasma MBG levels in patients with primary salt-sensitive and salt-insensitive hypertension. In total, 51 patients with primary hypertension were evaluated during acute sodium restriction and sodium loading. Plasma or serum concentrations of MBG, natriuretic pro-peptides, aldosterone, sodium, potassium, as well as hematocrit (Hct) value, plasma renin activity (PRA) and urinary sodium and potassium excretion were measured. Ambulatory blood pressure monitoring (ABPM) and echocardiography were performed at baseline. In salt-sensitive patients with primary hypertension plasma MBG correlated positively with diastolic blood pressure (ABPM) and serum NT-proANP concentration at baseline and with serum NT-proANP concentration after dietary sodium restriction. In this subgroup plasma MBG concentration decreased during sodium restriction, and a parallel increase of PRA was observed. Acute salt loading further decreased plasma MBG concentration in salt-sensitive subjects in contrast to salt insensitive patients. No correlation was found between plasma MBG concentration and left ventricular mass index. In conclusion, in salt-sensitive hypertensive patients plasma MBG concentration correlates with 24-h diastolic blood pressure and dietary sodium restriction reduces plasma MBG levels. Decreased MBG secretion in response to acute salt loading may play an important role in the pathogenesis of salt sensitivity.
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Łabno-Kirszniok et al. (2021) studied Primary hypertension (n=51). Short-term changes in sodium intake (restriction and loading) vs. Salt-insensitive patients / Baseline was evaluated on Plasma marinobufagenin (MBG) levels. Short-term dietary sodium restriction and acute salt loading decreased plasma marinobufagenin levels in salt-sensitive hypertensive patients, in contrast to salt-insensitive patients.
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