Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1968Diabetes

Glucose-Fatty Acid Interactions in the Rat Diaphragm in Vivo

View Full Paper
Ask AI
Bookmark
Share

Population

Intact rats, including seventy-two hour alloxan diabetic rats

Design

Preclinical

Authors

GSGustav SchonfeldSprint (United States)DKDavid KipnisUniversity of Maryland, Baltimore

Discussion

Loading...

Member takes

Implication

Shifts emphasis to tissue over plasma FFA in rat muscle glucose handling; leaves open relevance to human diabetes.

Structured PICO

P
Population
Intact rats, including seventy-two hour alloxan diabetic rats
I
Intervention
Acute elevations of plasma free fatty acid (FFA) via fat meal-heparin regimen or intravenous injection of anti-insulin serum, with concomitant glucose load and insulin
O
Outcome
Intracellular accumulation of free glucose in the rat diaphragmsurrogate

The tissue fatty acid moiety, rather than plasma FFA levels, appears to be the major determinant in glucose-fatty acid interactions in striated muscle.

Cite This Study

Schonfeld et al. (1968) studied this question.

synapsesocial.com/papers/6a71d536f44fa9f079df864chttps://doi.org/10.2337/diab.17.7.422
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Free Fatty Acids Inhibit the Glucose-Stimulated Increase of Intramuscular Glucose-6-Phosphate Concentration in Humans12001 · 78 citations
  2. 2Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.1999 · 1,273 citations
  3. 3Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo.1992 · 316 citations
  4. 4Effects of Free Fatty Acids and Glucose on Splanchnic Insulin Dynamics1997 · 91 citations
  5. 5Defective Liver Disposal of Free Fatty Acids in Patients with Impaired Glucose Tolerance2004 · 45 citations