Key result
Preconditioning with low-energy shock waves significantly enhanced recruitment of endothelial progenitor cells and improved relative blood flow recovery in chronic ischemia (P<0.05).
Why the study?
Does low-energy shock wave therapy improve recruitment of endothelial progenitor cells and blood flow recovery in rat models of chronic ischemia?
Population
Nude rats (hind limb adductor muscles, nonischemic and chronic hind limb ischemia models)
Comparison
Focused low-energy extracorporeal shock wave… vs Untreated rats
Design
Preclinical
Follow-up
24 hours (for EPC infusion)
Authors
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Hypothesis-generating in rat ischemia models; leaves open translation of shock wave preconditioning to human therapy.
Does low-energy shock wave therapy improve recruitment of endothelial progenitor cells and blood flow recovery in rat models of chronic ischemia?
p-value: p=<0.05
Preconditioning ischemic tissue with low-energy shock waves enhances the recruitment of circulating endothelial progenitor cells and improves blood flow recovery in a preclinical model.
Aicher et al. (2006) studied Chronic ischemia. Focused low-energy shock wave (SW) vs. Untreated was evaluated on mRNA expression of stromal cell-derived factor 1, VEGF-positive endothelial cells, and relative blood flow recovery (p=<0.05). Preconditioning with low-energy shock waves significantly enhanced recruitment of endothelial progenitor cells and improved relative blood flow recovery in chronic ischemia (P<0.05).
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