July 1, 1991AJP Endocrinology and Metabolism
Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits
Population
Streptozocin-treated rats with durations of diabetes from 1 wk to 4 mo, normal rats rendered hyperglycemic…
Comparison
Streptozocin-induced diabetes, acute… vs Normal rats
Design
Preclinical
Follow-up
1 week to 4 months
Authors
Discussion
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Implication
Endoneurial hypoxia may contribute to early diabetic neuropathy; hypothesis-generating in animals and should not yet change practice.
Structured PICO
P
Population
Streptozocin-treated rats with durations of diabetes from 1 wk to 4 mo, normal rats rendered hyperglycemic by glucose infusion, and 2-mo diabetic rats
I
Intervention
Streptozocin-induced diabetes, acute hyperglycemia via glucose infusion, or guanethidine treatment
C
Comparator
Normal rats
O
Outcome
Sciatic nerve endoneurial blood flow and conduction velocitysurrogate
Hyperglycemia-induced blood flow reductions and resultant endoneurial hypoxia are important factors underlying nerve conduction deficits early in the development of diabetic neuropathy.
Cite This Study
Cameron et al. (1991) studied this question.