Why the study?
Does low-dose phenylephrine commenced prior to induction of anaesthesia improve mean arterial blood pressure, stroke volume, and cardiac output in high-risk older patients undergoing major peripheral vascular surgery?
Does low-dose phenylephrine commenced prior to induction of anaesthesia improve mean arterial blood pressure, stroke volume, and cardiac output in high-risk older patients undergoing major peripheral vascular surgery?
Absolute Event Rate: 94% vs 24%
Absolute Risk Reduction: 70%
A retrospective study was conducted to analyze the hemodynamic effects of pre-induction phenylephrine in high-risk vascular surgery patients, though specific results were not reported in the provided abstract.
May enhance prescription quality in critical care; leaves open effects on outcomes and generalizability.
Fall in mean arterial blood pressure (MAP) during anaesthetic induction is common and may result in profound hypotension. Using the LiDCORapid (LiDCO Ltd, UK), we previously demonstrated that the fall in MAP is usually driven by a reduction in stroke volume (SV) that was presumed due to venodilation. Low- dose phenylephrine (PE), a venoconstrictor, commenced immediately prior to induction ameliorated these effects to a significant degree [ 1 ]. However, it is important that the pre-induction administration of PE should not cause any marked changes in MAP and CO. We retrospectively studied a group of 40 high-risk patients about to undergo major peripheral vascular surgery where PE was commenced immediately pre-induction. The haemodynamic effects of this dose of PE on MAP, SV and CO were analysed.
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Araujo et al. (2014) studied Prescribing errors (n=240). Standardised prescription stickers and education vs. Standard practice (pre-intervention) was evaluated on Prescriptions fulfilling best practice criteria.
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