The paper discusses the hypothesis that cellular mutations are required for full viral transformation by papovaviruses like SV40.
May require cellular mutations for full papovavirus transformation; leaves open validation in disease models before any clinical consideration.
As Temin (this volume) pointed out, tumor viruses and chemical carcinogens apparently differ in their modes of action. Chemical carcinogens seem to cause random changes in the genetic material (Ames 1979), whereas oncogenic viruses appear to introduce new specific genetic information into the affected cell. In particular, in the case of SV40, a functional A gene appears to play a crucial role in the establishment and maintenance of transformation (see Crawford, this volume). On the other hand, several results have been obtained suggesting that cellular mutations may be necessary for full expression of the transformed state after infection with papovaviruses (Dulbecco 1976).
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Theile et al. (1980) studied this question.
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