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November 1, 1964Proceedings of the National Academy of SciencesOpen Access

Synthesis of Sv40 Tumor Antigen During Replication of Simian Papovavirus (Sv40)

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Population

Hamsters bearing tumors induced either by simian papovavirus 40 or by cells transformed in vitro by the…

Design

Preclinical

Authors

FRFred RappBoston UniversityTKT. KitaharaStatens Serum InstitutJBJanet S. ButelBaylor College of Medicine

Discussion

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Overview

May guide SV40 oncology models; leaves open human translation.

Structured PICO

P
Population
Hamsters bearing tumors induced either by simian papovavirus 40 (SV40) or by cells transformed in vitro by the virus, and cells susceptible to SV40
I
Intervention
Simian papovavirus (SV40) replication
O
Outcome
Synthesis of SV40 tumor antigensurrogate

The study investigates the synthesis of SV40 tumor antigens during viral replication in susceptible cells.

Cite This Study

Rapp et al. (1964) studied this question.

synapsesocial.com/papers/6a77cbc998f24dbf64bd9d0fhttps://doi.org/10.1073/pnas.52.5.1138
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Papovavirus SV40: Similarity of tumor antigens in transformed virus‐free hamster cells and in virus‐infected monkey cells1966 · 1 citations
  2. 2Development of Antibodies Against Viral and Tumor Antigens of Papovavirus SV40 in Monkeys1967 · 12 citations
  3. 3Tumorigenicity of Simian Papovavirus SV40 and of Virus-Transformed Cells<xref ref-type="fn" rid="FN1">2</xref>1963 · 97 citations
  4. 4Antibodies Reacting to Simian Virus 40 T Antigen in Human Sera1973
  5. 5Papovavirus SV40 Transplantation Immunity Conferred by an Adenovirus-SV40 Hybrid21966 · 34 citations