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June 1, 1963JNCI Journal of the National Cancer Institute

Tumorigenicity of Simian Papovavirus SV40 and of Virus-Transformed Cells2

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Population

Newborn hamsters, human fibroblast cultures derived from embryonic lung, and hamster embryo cells

Design

Preclinical

Follow-up

2 to 3 months (for antibody testing after tumor appearance)

Authors

AAAsaria AshkenaziKaplan Medical CenterJMJoseph L. MelnickStatens Serum Institut

Discussion

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Overview

SV40 tumorigenicity in animal models leaves open human cancer relevance; further evidence required before clinical consideration.

Structured PICO

P
Population
Newborn hamsters, human fibroblast cultures derived from embryonic lung, and hamster embryo cells
I
Intervention
Inoculation or infection with simian papovavirus SV40 or SV40-transformed cells
O
Outcome
Tumor development, virus recovery, antibody production, and cell transformation

SV40 is tumorigenic in hamsters and can transform human and hamster cells in vitro, with transformed hamster cells producing highly cellular, metastatic tumors upon inoculation.

Cite This Study

Ashkenazi et al. (1963) studied this question.

synapsesocial.com/papers/6a7c0df8073f483584dfb376https://doi.org/10.1093/jnci/30.6.1227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Papovavirus SV40: Similarity of tumor antigens in transformed virus‐free hamster cells and in virus‐infected monkey cells1966 · 1 citations
  2. 2SYNTHESIS OF SV40 TUMOR ANTIGEN DURING REPLICATION OF SIMIAN PAPOVAVIRUS (SV40)1964 · 131 citations
  3. 3Papovavirus SV40 Transplantation Immunity Conferred by an Adenovirus-SV40 Hybrid21966 · 34 citations
  4. 4Virus Production Induced by Various Chemical Carcinogens in a Virogenic Hamster Cell Carcinogens in a Line Transformed Virus1972
  5. 5Long-Term Follow-up of Persons Inadvertently Inoculated with SV40 as Neonates1981 · 108 citations