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June 20, 2026JNCI Journal of the National Cancer Institute

Antibodies Reacting to Simian Virus 40 T Antigen in Human Sera

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Authors

KSKeerti V. ShahUniversity of LondonRDRichard W. DanielGMGerald Murphy

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Overview

The study identifies SV40 T antigen antibodies in young renal transplant recipients, indicating viral interactions.

Key Points

  • This research aims to detect antibodies reacting to SV40 T antigen in human sera, particularly in renal transplant recipients.
  • Analyzed serum specimens from a young renal transplant recipient for antibodies against SV40 T antigen and B.K. virus.
  • Performed fluorescent antibody tests to detect SV40 T antigen-reactive antibodies.
  • Compared antibody presence in 30 Maryland children with varying B.K. virus titers.
  • In the young renal transplant recipient, high titers of B.K. virus antibodies were found; SV40-neutralizing antibodies were minimal or undetectable.
  • 2 out of 30 Maryland children had SV40 T antigen-reactive antibodies at high B.K. virus titers (1:640), while none from a group with lower titers.
  • SV40 T antibodies stained the nuclei of B.K. virus-infected vero cells, indicating an antigenic relationship.

Cite This Study

Shah et al. (1973) studied this question.

synapsesocial.com/papers/6a362ebddb0793dc1a536576https://doi.org/10.1093/jnci/51.2.687
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Also Consider

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  1. 1Lack of Serologic Evidence for Prevalent Simian Virus 40 Infection in Humans2003 · 111 citations
  2. 2Papovavirus SV40: Similarity of tumor antigens in transformed virus‐free hamster cells and in virus‐infected monkey cells1966 · 1 citations
  3. 3SYNTHESIS OF SV40 TUMOR ANTIGEN DURING REPLICATION OF SIMIAN PAPOVAVIRUS (SV40)1964 · 131 citations
  4. 4Development of Antibodies Against Viral and Tumor Antigens of Papovavirus SV40 in Monkeys1967 · 12 citations
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