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July 1, 1967Experimental Biology and Medicine

Development of Antibodies Against Viral and Tumor Antigens of Papovavirus SV40 in Monkeys

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Key result

Injection of undiluted papovavirus SV40 induced complement-fixing and neutralizing antibodies against structural antigens in all 4 monkeys, and against the T antigen in 3 monkeys.

Authors

VVV. VonkaInstitute of Haematology and Blood TransfusionHZH ZávadováLKL Kutinová

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Implication

SV40 induces antibodies in monkeys; leaves open human immunogenicity, safety, and oncogenicity questions.

PICO

P
Population
4 monkeys injected with undiluted papovavirus SV40 to study the development of viral and tumor antigen antibodies.
I
Intervention / Comparator
Undiluted papovavirus SV40 (Undiluted)
O
Primary Outcome
Development of complement-fixing and neutralizing antibodies against structural and T antigens

Cite This Study

Vonka et al. (1967) studied Papovavirus SV40 infection (n=4). Undiluted papovavirus SV40 was evaluated on Development of complement-fixing and neutralizing antibodies against structural and T antigens. Injection of undiluted papovavirus SV40 induced complement-fixing and neutralizing antibodies against structural antigens in all 4 monkeys, and against the T antigen in 3 monkeys.

synapsesocial.com/papers/6a9ed93828ef650d2c9161f1https://doi.org/10.3181/00379727-125-32207
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Papovavirus SV40: Similarity of tumor antigens in transformed virus‐free hamster cells and in virus‐infected monkey cells1966 · 1 citations
  2. 2SYNTHESIS OF SV40 TUMOR ANTIGEN DURING REPLICATION OF SIMIAN PAPOVAVIRUS (SV40)1964 · 131 citations
  3. 3Papovavirus SV40 Transplantation Immunity Conferred by an Adenovirus-SV40 Hybrid21966 · 34 citations
  4. 4Antibodies Reacting to Simian Virus 40 T Antigen in Human Sera1973 · 13 citations
  5. 5Characterization of Hamster Antibody Reacting with Papovavirus SV40 Tumor Antigen1967 · 9 citations