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December 1, 1975JNCI Journal of the National Cancer Institute

Natural and Experimentally Induced Antibodies to Defined Mammalian Type-C Virus Proteins in Primates2

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Key result

Primates, including humans immunized with R-MuLV, demonstrated the ability to form antibodies to well-characterized proteins from endogenous and exogenous type-C viruses.

Population

16 clinically normal gibbons, 4 experimentally inoculated gibbons, 1 woolly monkey, 20 human patients, and…

Design

Preclinical

Authors

HCHoward P. CharmanNational Cancer InstituteNKN. KimMWMartin H. WhiteCancer Research Center

Discussion

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Implication

May support seroepidemiologic studies of type-C viruses; leaves open human clinical relevance pending validation.

Study Design

Type

Observational

Structured PICO

P
Population
Primates, including 20 human patients immunized with R-MuLV and various non-human primates, assessed for antibodies to type-C virus proteins.
E
Exposure
Immunization or natural exposure to mammalian type-C virus proteins (GaLV, simian sarcoma virus, R-MuLV, RD114, baboon leukemia virus)
O
Outcome
Antibody formation to viral proteins (p30, gp70) detected by radioimmunoprecipitation assayssurrogate

Primates, including humans, can form antibodies to well-characterized proteins from endogenous and exogenous type-C viruses, suggesting utility for seroepidemiologic studies.

Cite This Study

Charman et al. (1975) conducted an observational in Exposure to or immunization against type-C viruses. Exposure to or immunization with type-C RNA tumor viruses was evaluated on Formation of antibodies to type-C virus proteins. Primates, including humans immunized with R-MuLV, demonstrated the ability to form antibodies to well-characterized proteins from endogenous and exogenous type-C viruses.

synapsesocial.com/papers/6a97c202c5cc395bb1e1723ahttps://doi.org/10.1093/jnci/55.6.1419
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunochemical Studies of the Major Internal Polypeptide of Woolly Monkey and Gibbon APE Type C Viruses1974 · 33 citations
  2. 2Comparisons of the immunological properties of two structural polypeptides of type C RNA viruses endogenous to old world monkeys1976 · 25 citations
  3. 3Enhanced induction of growth of B lymphoblasts from fresh human blood by primate type‐C retroviruses (gibbon ape leukemia virus and simian sarcoma virus)1979 · 30 citations
  4. 4Monoclonal antibodies against baboon endogenous virus and against host cell antigens1982 · 15 citations
  5. 5Development of Antibodies Against Viral and Tumor Antigens of Papovavirus SV40 in Monkeys1967 · 12 citations