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March 1, 1974The Journal of Immunology

Immunochemical Studies of the Major Internal Polypeptide of Woolly Monkey and Gibbon APE Type C Viruses

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Key result

The major internal protein of the Woolly monkey type C virus showed a high degree of immunochemical relationship to the Gibbon ape type C virus and cross-reactivity with other mammalian type C viruses.

Population

Type C virus isolated from a Woolly monkey and Gibbon ape

Design

Preclinical

Authors

RGRaymond V. GildenMeadowlark Optics (United States)RTRobert ToniNational Institutes of HealthMHMichelle Hanson

Discussion

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Implication

Supports type C virus antigen sharing across mammals; leaves open any human translational relevance.

Structured PICO

P
Population
Type C virus isolated from a Woolly monkey and Gibbon ape
E
Exposure
Purification of the major internal protein by isoelectric focusing and raising specific antibody in guinea pigs
O
Outcome
Protein characteristics (isoelectric point, molecular weight) and cross-reactivitysurrogate

The major internal protein of Woolly monkey type C virus shares significant cross-reactivity with Gibbon ape type C virus and contains determinants cross-reactive with other mammalian type C viruses.

Cite This Study

Gilden et al. (1974) studied this question. Purified major internal protein of Woolly monkey type C virus vs. Gibbon ape type C virus and other mammalian type C viruses was evaluated on Immunochemical relationship and cross-reactivity. The major internal protein of the Woolly monkey type C virus showed a high degree of immunochemical relationship to the Gibbon ape type C virus and cross-reactivity with other mammalian type C viruses.

synapsesocial.com/papers/6a9d4d1b34685bd77029f8d2https://doi.org/10.4049/jimmunol.112.3.1250
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparisons of the immunological properties of two structural polypeptides of type C RNA viruses endogenous to old world monkeys1976 · 25 citations
  2. 2Natural and Experimentally Induced Antibodies to Defined Mammalian Type-C Virus Proteins in Primates21975 · 33 citations
  3. 3Radioimmunoassay of Mammalian Type C Viral Proteins1972 · 71 citations
  4. 4Primate and Murine Type-C Viral Nucleic Acid Association Kinetics: Analysis of Model Systems and Natural Tissues1974 · 111 citations
  5. 5Primate Retroviruses: Biochemical Characterization Based on the Isoelectric Points of the Envelope Glycoproteins1978