Key result
Emerging anti-remodeling therapies, including micro-RNA modulation, post-translational modifications like HMGB-1, and microsphere-based delivery systems, offer potential new strategies for treating post-ischemic heart failure.
Emerging biological therapies targeting micro-RNAs, HMGB-1, and utilizing microspheres hold promise for preventing or reversing cardiac remodeling after myocardial infarction, though large-scale clinical trials are still needed.
These strategies remain investigational in post-ischemic HF; prospective trials needed before clinical consideration.
In recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regulate the response of cardiac tissue to ischemic injury. These involve various cell types such as fibroblasts, cells of the immune system, endothelial cells, cardiomyocytes and stem cells, as well as a myriad of mediators belonging to the system of cytokines and not only. In parallel with the latest findings on post-infarct remodeling, new potential therapeutic targets are arising to halt the progression of disease. After the evaluation of the results obtained from gene therapy and stem cells, in this part we evaluate micro- RNA, post-translational modification and microspheres based therapy.
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Salzano et al. (2015) conducted a review in Post-ischemic chronic heart failure and cardiac remodeling. Anti-remodeling therapies (micro-RNA, HMGB-1 modulation, microspheres) was evaluated. Emerging anti-remodeling therapies, including micro-RNA modulation, post-translational modifications like HMGB-1, and microsphere-based delivery systems, offer potential new strategies for treating post-ischemic heart failure.
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