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December 1, 1999American Journal of Respiratory Cell and Molecular Biology

Hypoxia Upregulates Activity and Expression of the Glucose Transporter GLUT1 in Alveolar Epithelial Cells

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Authors

AOAchour OuiddirInsermCPCarole PlanèsInsermIFIsabelle FernandesFundação Padre Albino

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Implication

Randomized trial shows hypoxia increases GLUT1 in alveolar epithelial cells, indicating a mechanism for energy adaptation.

Key Points

  • The study aims to investigate how hypoxia affects glucose transport and GLUT1 expression in alveolar epithelial cells.
  • Examined the effect of hypoxia on glucose transport in primary rat alveolar epithelial cells.
  • Measured 2-deoxy-D-glucose uptake under varying O2 conditions and times.
  • Investigated GLUT1 mRNA levels using treatments with cobalt chloride and Na azide.
  • Hypoxia induced a 3-fold increase in GLUT1 protein and mRNA levels in alveolar epithelial cells (p < 0.01).
  • Anaerobic glycolysis was maintained to preserve the energy status during hypoxia, compared to normoxic cells.
  • Cobalt chloride and Na azide treatments mimicked the hypoxic increase in GLUT1 mRNA and glucose uptake.

Cite This Study

Ouiddir et al. (1999) studied this question.

synapsesocial.com/papers/6a71db678031ec7bb1dd22c5https://doi.org/10.1165/ajrcmb.21.6.3751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins.1991 · 179 citations
  2. 2Glucose regulates glut 1 function and expression in fetal rat lung and muscle in vitro.1993 · 41 citations
  3. 3Hypoxia induces glucose transporter expression in endothelial cells1992 · 182 citations
  4. 4Isolation and culture of alveolar type II cells1990 · 375 citations
  5. 5Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung1998 · 377 citations