What question did this study set out to answer?

To design and evaluate a broad-band optimal ventilator waveform that accurately estimates low-frequency respiratory resistance and elastance while maintaining ventilation and minimizing peak airway pressures.

July 1, 1993Journal of Applied Physiology

Optimal ventilation waveforms for estimating low-frequency respiratory impedance

View Full Paper

Ask AI

Bookmark

Authors

KLKenneth R. LutchenBoston University KYKuender D. YangNational Yang Ming Chiao Tung University DKDavid W. KaczkaUniversity of Iowa

Discussion

Member takes

Implication

Physiological study demonstrates broad-band optimal ventilation waveforms reliably estimate low-frequency respiratory impedance in healthy and asthmatic subjects, highlighting dynamic lung...

Key Points

To design and evaluate a broad-band optimal ventilator waveform that accurately estimates low-frequency respiratory resistance and elastance while maintaining ventilation and minimizing peak airway pressures.
Engineered broad-band optimal ventilator waveforms (0.1–2.4 Hz) with optimized phase alignments to minimize peak-to-peak airway opening pressure and nonlinear harmonic distortions while ensuring adequate gas exchange.
Tested waveforms via computer simulations (branching airway and viscoelastic models) and physiological delivery through a servo-controlled oscillator in healthy human subjects and one symptomatic asthmatic subject pre- and post-bronchodilation.
Simulations demonstrated that optimal ventilator waveforms substantially outperformed standard step ventilator waveforms in estimating respiratory resistance and elastance between 0.1 and 2 Hz by reducing harmonic interactions.
Human testing confirmed the optimal waveform reliably yielded smooth impedance estimates, detecting pronounced elevations in resistance and elastance in an asthmatic subject that resolved following bronchodilator therapy.

Cite This Study

Lutchen et al. (1993) studied this question.

synapsesocial.com/papers/6a71dc95a528af2d65c43a7e https://doi.org/10.1152/jappl.1993.75.1.478

View Full Paper

Ask AI

Bookmark

Implication

Physiological study demonstrates broad-band optimal ventilation waveforms reliably estimate low-frequency respiratory impedance in healthy and asthmatic subjects, highlighting dynamic lung...

Optimal ventilation waveforms for estimating low-frequency respiratory impedance

Discussion

Member takes

Implication

Key Points

Cite This Study

Optimal ventilation waveforms for estimating low-frequency respiratory impedance

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider