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May 21, 2008AJP Endocrinology and MetabolismOpen Access

Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity

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Population

Male C57BL/6J-Lepob and C57BL/6J mice, primary murine peritoneal macrophages, and murine cell lines.

Comparison

Macrophage deletion via clodronate liposome… vs Lean C57BL/6J mice, normoxic conditions, or…

Design

Preclinical

Authors

CPCan PangNational Center for AIDS/STD Control and Prevention,China CDCZGZhan‐Guo GaoBrown FoundationJYJun YinInner Mongolia Agricultural University

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for macrophage PDGF in adipose angiogenesis.

Structured PICO

P
Population
Male C57BL/6J-Lepob (ob/ob) and C57BL/6J mice (6 weeks old), primary murine peritoneal macrophages, and murine cell lines (SVEC4-10 endothelial cells, 3T3-L1 adipocytes, RAW 264.7 macrophages).
I
Intervention
Macrophage deletion via clodronate liposome (100-150 mg/kg ip), hypoxia treatment (1% oxygen), recombinant PDGF, and PI3K/mTOR/S6K pathway inhibition (LY-294002, wortmannin, rapamycin, S6K dominant-negative mutant).
C
Comparator
Lean C57BL/6J mice, normoxic conditions, or vehicle/control treatments.
O
Outcome
Endothelial cell density (CD31 expression), PDGF expression (mRNA and protein), and endothelial cell tube formation.surrogate

Macrophage infiltration in obese adipose tissue may be a compensatory mechanism to promote angiogenesis via PDGF secretion and the endothelial PI3K/mTOR/S6K pathway.

Cite This Study

Pang et al. (2008) studied this question.

synapsesocial.com/papers/6a71de36ce524a4339c52d12https://doi.org/10.1152/ajpendo.90296.2008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives1997 · 502 citations
  2. 2Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse1999 · 1,697 citations
  3. 3Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis2004 · 205 citations
  4. 4PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR2007 · 386 citations
  5. 5Angiogenesis and obesity2007 · 204 citations