Population
Rat alveolar macrophages, rat lung fibroblasts (RLF), and Swiss 3T3 cells
Comparison
Purified recombinant PDGF isoforms and alveolar… vs Control medium
Design
Preclinical
Follow-up
3 days
Authors
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May guide isoform-selective antifibrotic development; hypothesis-generating with human validation required.
Rat alveolar macrophages secrete all three PDGF isoforms, but PDGF-BB and -AB are the primary drivers of lung fibroblast proliferation, highlighting isoform-specific roles in lung fibrogenesis.
Bonner et al. (1991) studied this question.
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