Key result
Orthotopic heart transplantation followed by R-CHOP chemotherapy successfully treated a 53-year-old man with primary cardiac lymphoma, with reduced metastatic lesions at 12 months.
Why the study?
Does orthotopic heart transplantation combined with chemotherapy improve outcomes in a patient with primary cardiac lymphoma?
Case Report (n=1)
Does orthotopic heart transplantation combined with chemotherapy improve outcomes in a patient with primary cardiac lymphoma?
Orthotopic heart transplantation followed by R-CHOP chemotherapy may be a viable treatment strategy for primary cardiac lymphoma when complete resection is impossible and no extra-cardiac metastases are present.
May support transplant plus R-CHOP in select unresectable primary cardiac lymphoma; leaves open need for prospective validation before wider use.
We here describe the case of a patient diagnosed with primary lymphoma who underwent orthotopic heart transplantation.Post surgically, the patient was treated with immunosuppressants and chemotherapy. Three months later, lesions were found on the right side of the neck and the inferior vena cava; 12 months later, the lesion of the neck became smaller and the lesion of the inferior vena cava was not detected by positron emission tomography/computed tomography. The problems we encountered with this rare disease are discussed and compared to previous studies.
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Yang et al. (2013) conducted a case report in Primary cardiac lymphoma (n=1). Orthotopic heart transplantation and R-CHOP chemotherapy was evaluated on Survival and tumor recurrence. Orthotopic heart transplantation followed by R-CHOP chemotherapy successfully treated a 53-year-old man with primary cardiac lymphoma, with reduced metastatic lesions at 12 months.
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