Key result
Seropositivity against EV71 and CA16 was lowest in children aged 6-11 months (5.5% for EV71, 14.5-16.4% for CA16) and gradually increased with age, remaining below 50% in children younger than 3 years.
Population
579 subjects ranging in age from < 1 to 60 years old living in Nakhon Ratchasima Province, Thailand in 2013.
Design
Cross-sectional
Authors
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Warrants caution for HFMD exposure in infants under 3 years; leaves open prospective trials on age-specific vaccination.
Cross-Sectional (n=579)
Children under 3 years of age in Thailand have low seroprevalence of neutralizing antibodies to EV71 and CA16, making them highly vulnerable to hand, foot, and mouth disease.
Lerdsamran et al. (2018) conducted a cross-sectional in Hand, foot and mouth disease (HFMD) (n=579). Natural exposure to EV71 and CA16 was evaluated on Seroprevalence of neutralizing antibodies to EV71 and CA16 subgenotypes. Seropositivity against EV71 and CA16 was lowest in children aged 6-11 months (5.5% for EV71, 14.5-16.4% for CA16) and gradually increased with age, remaining below 50% in children younger than 3 years.
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