Key result
KCNQ1 single-nucleotide polymorphisms were significantly associated with type 2 diabetes (e.g., OR 1.48, P=3x10^-4 for rs2237897), likely caused by a reduction in insulin secretion.
Why the study?
Do KCNQ1 polymorphisms associate with type 2 diabetes, insulin resistance, and beta-cell function in a multi-ethnic Asian population?
Population
3,734 participants from the population-based 1998 Singapore National Health Survey cohort
Comparison
Presence of KCNQ1 single-nucleotide… vs Absence of the genetic risk alleles
Design
Cohort
Authors
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Supports KCNQ1 screening in at-risk Asians; extends genetic associations but remains hypothesis-generating for practice.
Cohort (n=3,734)
Do KCNQ1 polymorphisms associate with type 2 diabetes, insulin resistance, and beta-cell function in a multi-ethnic Asian population?
Odds Ratio: 1.48
p-value: p=3 x 10(-4)
KCNQ1 polymorphisms are associated with an increased risk of type 2 diabetes in Asian populations, likely driven by reduced insulin secretion.
Tan et al. (2009) conducted a cohort in Type 2 diabetes (n=3,734). KCNQ1 single-nucleotide polymorphisms (SNPs) was evaluated on Type 2 diabetes (OR 1.48, p=3 x 10(-4)). KCNQ1 single-nucleotide polymorphisms were significantly associated with type 2 diabetes (e.g., OR 1.48, P=3x10^-4 for rs2237897), likely caused by a reduction in insulin secretion.
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