Key result
The KCNQ1 variant rs2283228 risk allele (A) was significantly associated with an increased risk of type 2 diabetes in Malaysian Malay subjects (OR 1.7).
Case-Control (n=411)
No
Odds Ratio: 1.7 (95% CI 1.25–2.3)
p-value: p=0.0006
KCNQ1 genetic variants, including specific SNPs, haplotypes, and diplotypes, are significantly associated with susceptibility to Type 2 Diabetes in the Malaysian Malay population.
Association in Malays supports ethnic-specific T2D genetics; leaves open replication and clinical utility in prospective studies.
INTRODUCTION: Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects. MATERIALS AND METHODS: The KCNQ1 single nucleotide polymorphisms (SNPs): rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects. RESULTS: The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006). CONCLUSION: The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.
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Saif-Ali et al. (2011) conducted a case-control in Type 2 Diabetes (n=411). KCNQ1 variant rs2283228 (A allele) vs. Non-risk allele was evaluated on Type 2 diabetes susceptibility (OR 1.7, 95% CI 1.25-2.30, p=0.0006). The KCNQ1 variant rs2283228 risk allele (A) was significantly associated with an increased risk of type 2 diabetes in Malaysian Malay subjects (OR 1.7).
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