September 1, 1999AJP Cell Physiology

Status of Ca2+/calmodulin protein kinase phosphorylation of cardiac SR proteins in ischemia-reperfusion

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Population

Preclinical heart model (control, ischemic, and ischemia-reperfused hearts)

Comparison

Superoxide dismutase plus catalase treatment vs Control, ischemic, and ischemia-reperfused…

Design

Preclinical

Authors

TNThomas NetticadanAgriculture and Agri-Food Canada RTRana M. TemsahUniversity of Ottawa MOMitsuru OsadaToho University

Discussion

Member takes

Implication

Antioxidants may protect SR Ca handling in experimental I/R; leaves open clinical translation.

Structured PICO

Population

Preclinical heart model (control, ischemic, and ischemia-reperfused hearts)

Intervention

Superoxide dismutase (SOD) plus catalase (CAT) treatment

Comparator

Control, ischemic, and ischemia-reperfused hearts not treated with SOD plus CAT

Outcome

Sarcoplasmic reticulum (SR) protein phosphorylation by CaMK and PKA, CaMK- and PKA-stimulated Ca2+ uptake, and CaMK, PKA, and phosphatase activitiessurrogate

Oxidative stress during ischemia-reperfusion injury depresses sarcoplasmic reticulum CaMK activity and phosphorylation, which can be prevented by antioxidant treatment with SOD and catalase.

Cite This Study

Netticadan et al. (1999) studied this question.

synapsesocial.com/papers/6a71df82a528af2d65c43b9d https://doi.org/10.1152/ajpcell.1999.277.3.c384

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Status of Ca2+/calmodulin protein kinase phosphorylation of cardiac SR proteins in ischemia-reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Status of Ca2+/calmodulin protein kinase phosphorylation of cardiac SR proteins in ischemia-reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider