Population
Isolated rat hearts subjected to global ischemia for 30 min followed by 60 min of reperfusion (I/R)
Comparison
Perfusion with superoxide dismutase plus… vs Ischemia/reperfusion alone without scavengers
Design
Preclinical
Follow-up
90 minutes (30 min ischemia followed by 60 min reperfusion)
Authors
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Antioxidants may preserve SR function in animal I/R; leaves open clinical translation for human cardioprotection.
Oxyradicals participate in depressing sarcoplasmic reticulum Ca(2+) handling and gene expression during ischemia-reperfusion, and antioxidant treatment may improve cardiac function recovery by preserving SR function.
Temsah et al. (1999) studied this question.
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