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November 14, 2017QJMOpen Access

The efficacy and safety of bronchial thermoplasty in severe persistent asthma on extended follow-up

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Authors

AOA. O’ReillyIBIngrid BrowneDWDavid Watchorn

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Overview

Retrospective observational study reports long-term safety and reduced hospitalizations in severe persistent asthma, suggesting extended clinical benefits from bronchial thermoplasty.

Key Points

  • To evaluate the safety and extended clinical efficacy of bronchial thermoplasty in patients with severe persistent asthma four years after treatment.
  • Conducted a retrospective observational study of seven patients (N=7) treated with bronchial thermoplasty between 2012 and 2013 at an Irish severe asthma centre.
  • Tracked Asthma Control Test (ACT) scores, hospital admissions, exacerbations, medication usage, and forced expiratory volume in 1 second (FEV1) over a mean follow-up period of 49.42 months.
  • Median 12-month hospital admissions decreased from 3 at baseline to 1 at extended follow-up (P = 0.059), and median ACT scores trended upward from 9 to 13 (P = 0.249).
  • Mean FEV1 was 1.68 l before treatment and 1.46 l four years post-treatment (P = 0.237), with zero mortality reported across the cohort.

Cite This Study

O’Reilly et al. (2017) studied this question.

synapsesocial.com/papers/6a71e013f44fa9f079df8d2ehttps://doi.org/10.1093/qjmed/hcx221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma2024 · 7 citations
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  4. 4Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma2024
  5. 5Prognostic Predictors of Bronchial Thermoplasty for Symptom Control in Severe Asthma2026