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Long-term follow-up study demonstrates persistent airway smooth muscle reduction for over 10 years, suggesting enduring structural benefits from bronchial thermoplasty.
Bronchial thermoplasty has been proposed to improve asthma control by decreasing the mass of airway smooth muscle (ASM) [1]. Clinical trials with a 5-year follow-up have documented significant improvements of asthma control in terms of severe exacerbations, emergency department visits and quality of life [2–4]. The BT10+ study, a long-term follow-up of 45% of subjects enrolled in these clinical trials, showed that these clinical benefits have persisted with a good safety profile for 10.8–15.6 years (median 12.1 years) [5]. Previously, we showed that the decreased ASM persisted at 34.2 months (range 27–48 months) after bronchial thermoplasty [6]. Airway smooth muscle ablation induced by thermoplasty is maintained for >10 years along with the improvements in asthma control
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Gagnon et al. (2023) studied this question.
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