Key result
Severe vitamin D deficiency (<20 ng/mL) was associated with a nearly twofold higher odds of nonvalvular persistent atrial fibrillation compared to normal levels (>30 ng/mL) (OR 1.97).
Why the study?
Is low serum vitamin D associated with nonvalvular persistent atrial fibrillation in Chinese patients?
Case-Control (n=322)
No
Is low serum vitamin D associated with nonvalvular persistent atrial fibrillation in Chinese patients?
Odds Ratio: 1.97 (95% CI 1.34–2.97)
p-value: p=0.04
Low serum vitamin D levels are independently associated with nonvalvular persistent atrial fibrillation in Chinese patients without other cardiovascular diseases.
No change to AF management warranted; leaves open whether vitamin D deficiency contributes to persistent AF in Chinese patients.
BACKGROUND: Low vitamin D status has been associated with increased risk of cardiovascular disease. Atrial fibrillation (AF) is the most common cardiac arrhythmia. We evaluated the association between low vitamin D and AF. METHODS: We analyzed data from 162 Chinese patients with nonvalvular persistent AF and no other cardiovascular disease whose serum 25-hydroxyvitamin D [25(OH)D] levels were measured in our hospital (AF group). Healthy subjects without AF who underwent health screening at our hospital served as controls (non-AF group, n = 160). 25(OH)D was measured by chemiluminescence assay. RESULTS: The serum 25(OH)D level was significantly lower in the AF group than in the non-AF group (18.5 ± 10.3 vs 21.4 ± 10.7 ng/mL, P < 0.05). The high-sensitivity C-reactive protein (hsCRP) level was significantly higher in the AF group than in the non-AF group (0.35 ± 0.19 vs 0.2 ± 0.17 mg/dL, P < 0.01). The average left atrial diameter was significantly larger in the AF group than in the non-AF group (P < 0.01). The serum 25(OH)D level showed a negative correlation with left atrial diameter, hsCRP level, and pulmonary artery systolic pressure. Logistic regression analysis identified that 25(OH)D was related to AF. Patients whose vitamin D levels were in the lowest 25(OH)D category (<20 ng/mL) were more often in the AF group, with their incidence about twofold higher than those in the highest 25(OH)D category (>30 ng/mL). CONCLUSIONS: Low vitamin D levels are associated with AF. It may be involved in its development.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2013) conducted a case-control in Nonvalvular persistent atrial fibrillation (n=322). Vitamin D deficiency (<20 ng/mL) vs. Normal vitamin D levels (>30 ng/mL) was evaluated on Presence of atrial fibrillation (OR 1.97, 95% CI 1.34-2.97, p=0.04). Severe vitamin D deficiency (<20 ng/mL) was associated with a nearly twofold higher odds of nonvalvular persistent atrial fibrillation compared to normal levels (>30 ng/mL) (OR 1.97).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: