What is the clinical evidence from this study?

Study design: Observational. Population: Chronic myocardial infarction (n=20). Intervention: Fatty metaplasia vs. No fatty metaplasia. Primary outcome: Percentage of fibrosis (p=0.005).

June 15, 2017Magnetic Resonance Materials in Physics Biology and MedicineOpen Access

Fatty metaplasia quantification and impact on regional myocardial function as assessed by advanced cardiac MR imaging

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Key result

Patients with chronic myocardial infarction and fatty metaplasia demonstrated a significantly smaller percentage of fibrosis compared to those without fat deposition (10.68% vs. 13.83%).

Why the study?

Does mDixon LGE imaging improve the detection of fatty metaplasia and characterization of regional myocardial function compared to conventional LGE in patients with chronic myocardial infarction?

Population

20 subjects with chronic myocardial infarction (infarct age median 60.0 months; range 13.0-90.0 months)

Comparison

Advanced cardiac MR imaging including mDixon LGE… vs Conventional late gadolinium enhancement CMR…

Design

Cohort

Authors

TLTomas LapinskasLithuanian Ornithological Society BSBernhard SchnackenburgPhilips (Germany)MKMarc KouwenhovenPhilips (Finland)

Discussion

Member takes

Implication

Fatty metaplasia may mark less fibrosis in chronic MI; leaves open its role in remodeling and prognosis.

Study Design

Type

Observational (n=20)

Multicenter

Structured PICO

Does mDixon LGE imaging improve the detection of fatty metaplasia and characterization of regional myocardial function compared to conventional LGE in patients with chronic myocardial infarction?

Population

20 patients with chronic myocardial infarction evaluated retrospectively to assess the impact of fatty metaplasia on regional myocardial function using advanced cardiac magnetic resonance imaging.

Exposure

Advanced cardiac MR imaging including mDixon LGE imaging for fat-water separation and feature tracking

Comparator

Conventional late gadolinium enhancement (LGE) CMR imaging

Outcome

Detection of lipomatous metaplasia, extent of global scar, and regional myocardial function (circumferential and radial strain)surrogate

Main Result

Absolute Event Rate: 10.68% vs 13.83%

p-value: p=0.005

Advanced CMR with mDixon imaging enables the detection of fatty metaplasia in chronic myocardial infarction, which is associated with altered regional myocardial deformation and cannot be detected by conventional LGE.

Limitations

Small population size
Wide variety of MI characteristics in terms of age, treatment, and location
Subjects were mostly long-term survivors with preserved LV systolic function
Risk factors leading to fat deposition have not been investigated

Cite This Study

Lapinskas et al. (2017) conducted an observational in Chronic myocardial infarction (n=20). Fatty metaplasia vs. No fatty metaplasia was evaluated on Percentage of fibrosis (p=0.005). Patients with chronic myocardial infarction and fatty metaplasia demonstrated a significantly smaller percentage of fibrosis compared to those without fat deposition (10.68% vs. 13.83%).

synapsesocial.com/papers/6a71e19e26a7f98052de05fb https://doi.org/10.1007/s10334-017-0639-7

Topics

Cardiac MRI Cardiac imaging

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Fatty metaplasia quantification and impact on regional myocardial function as assessed by advanced cardiac MR imaging

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Fatty metaplasia quantification and impact on regional myocardial function as assessed by advanced cardiac MR imaging

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider