Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease
Key result
Cardiac ionizing procedures in children with congenital heart disease were associated with a higher frequency of chromosomal aberrations (2.8% vs 0.7%; P<0.0001) compared to healthy controls.
Why the study?
Do cardiac procedures employing ionizing radiation increase chromosomal damage in children with congenital heart disease?
Population
74 subjects: 32 children with congenital heart disease exposed to ionizing radiation, 32 healthy age- and…
Comparison
Cardiac procedures employing ionizing radiation… vs Healthy age- and sex-matched subjects and…
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support radiation minimization research in pediatric congenital heart disease; leaves open clinical implications of chromosomal aberrations.
Study Design
Type
Observational (n=74)
Structured PICO
Do cardiac procedures employing ionizing radiation increase chromosomal damage in children with congenital heart disease?
P
Population
74 subjects including 32 children with congenital heart disease exposed to cardiac ionizing procedures, 32 healthy matched controls, and 10 non-exposed newborns.
E
Exposure
Cardiac procedures employing ionizing radiation (mostly cardiac catheterization) between 1965 and 2000 (mean 2.9+/-1.4 procedures per person).
C
Comparator
Healthy age- and sex-matched subjects and newborn non-exposed patients with CHD.
O
Outcome
Frequency of chromosomal aberrations (CA) and micronucleus assay (MN) in peripheral blood lymphocytes.surrogate
Main Result
Absolute Event Rate: 2.8% vs 0.7%
p-value: p=<0.0001
Cardiac catheterization involving ionizing radiation in children with congenital heart disease is associated with long-term chromosomal damage, highlighting the need for radiation dose optimization.
Cite This Study
Andreassi et al. (2006) conducted an observational in Congenital heart disease (n=74). Cardiac procedures employing ionizing radiation vs. Healthy matched subjects and non-exposed newborns was evaluated on Frequency of chromosomal aberrations (CA) (p=<0.0001). Cardiac ionizing procedures in children with congenital heart disease were associated with a higher frequency of chromosomal aberrations (2.8% vs 0.7%; P<0.0001) compared to healthy controls.