Why the study?
Does a high preoperative soluble thrombomodulin level affect coagulation, inflammation, blood loss, and DVT risk in patients undergoing total large joint replacement?
Does a high preoperative soluble thrombomodulin level affect coagulation, inflammation, blood loss, and DVT risk in patients undergoing total large joint replacement?
High preoperative soluble thrombomodulin levels are associated with increased blood loss but potentially lower DVT risk after major orthopedic surgery.
Background: A high level of soluble thrombomodulin (sTM) is associated with a lower risk of thrombosis but can cause severe bleeding after operations. Deep vein thrombosis (DVT) and blood loss are serious threats after orthopedic surgery. The aim of our pilot study was to evaluate the effect of the preoperative level of sTM on coagulation and inflammation as well as the blood loss and the development of symptomatic DVT after total large joint replacement.
No takes yet. Share an insight, caveat, or question.
Антропова et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: