Key result
Intensive blood pressure treatment targeting a systolic blood pressure of 110 to <130 mmHg reduced the risk of primary cardiovascular events by 26% compared to standard treatment in older hypertensive patients.
Why the study?
With a rapidly aging population, adequate blood pressure control is critical, prompting a review of clinical trials, the STEP study findings, and management perspectives in Asia.
Does intensive blood pressure treatment reduce cardiovascular events in elderly Asian hypertensive patients compared to standard treatment?
Design
Review
Authors
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Intensive SBP <120 mmHg benefits older adults; confirms SPRINT and extends BPLTTC meta-analysis to broader elderly populations.
Does intensive blood pressure treatment reduce cardiovascular events in elderly Asian hypertensive patients compared to standard treatment?
Effect estimate: reduced the risk by 26%
Absolute Event Rate: 3.5% vs 4.6%
This review emphasizes that intensive blood pressure control (SBP <130 mmHg) provides significant cardiovascular benefits for elderly Asian hypertensive patients, supporting tailored but stricter BP targets.
Zhang et al. (2022) conducted a review in Hypertension (n=8,511). Intensive BP-lowering treatment vs. Standard treatment (SBP target 130 to <150 mmHg) was evaluated on Composite of acute coronary syndrome, stroke, acute decompensated heart failure, coronary revascularization, atrial fibrillation, or death from cardiovascular causes (reduced the risk by 26%). Intensive blood pressure treatment targeting a systolic blood pressure of 110 to <130 mmHg reduced the risk of primary cardiovascular events by 26% compared to standard treatment in older hypertensive patients.
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