Population
Rats (in vivo) and aortic rings (in vitro)
Comparison
Asymmetric dimethylarginine via… vs Isotonic saline, l-arginine, and l-NAME
Design
Preclinical
Authors
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ADMA's central hypotensive effects in animals should not change practice; hypothesis-generating for its dual central-peripheral regulation of blood pressure.
ADMA regulates cardiovascular function through both central mechanisms (decreasing blood pressure and heart rate) and peripheral mechanisms (inhibiting endothelial NOS and increasing blood pressure).
Jin et al. (1996) studied this question.
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