Why the study?
Does pharmacological intervention with NO donors reverse the regional and cardiac haemodynamic effects of NO synthase inhibition by ADMA or L-NMMA in conscious rats?
Population
38 conscious male Long Evans rats, chronically instrumented for the measurement of regional or cardiac…
Comparison
NG,NG,dimethyl-L-arginine or… vs Isotonic saline infusion or baseline measurements.
Design
Preclinical, Experiments were performed, in random order, over several days.
Follow-up
Acute (minutes to hours)
Authors
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NO donors may normalize pressure without fully reversing vasoconstriction after NOS inhibition in rats; leaves open translation to human hemodynamics.
Does pharmacological intervention with NO donors reverse the regional and cardiac haemodynamic effects of NO synthase inhibition by ADMA or L-NMMA in conscious rats?
Pharmacological intervention with NO donors can normalize mean arterial pressure following NO synthesis inhibition without necessarily returning all associated cardiovascular variables to normal.
Gardiner et al. (1993) studied this question.
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