Key result
Clevidipine demonstrated favorable efficacy and promising safety profiles for the intraoperative management of hypertension in cardiac and noncardiac surgical settings.
Why the study?
Perioperative hypertension frequently leads to unfavorable cardiac complications, creating a need to synthesize literature on the use of clevidipine, an antihypertensive with an ultra-short half-life and titratable effect.
Does clevidipine improve the management of hypertension in patients in the perioperative cardiac and noncardiac surgical settings compared to placebo or other antihypertensives?
Systematic Review (n=2,066)
Does clevidipine improve the management of hypertension in patients in the perioperative cardiac and noncardiac surgical settings compared to placebo or other antihypertensives?
Clevidipine is an effective and safe ultra-short acting antihypertensive agent for managing acute perioperative hypertension in cardiac and noncardiac surgery.
Clevidipine shows favorable efficacy and safety for perioperative hypertension; extends evidence base but leaves open questions in frail and diverse populations.
Introduction: Perioperative hypertension is a common occurrence in anesthetic practice, potentially leading to cardiac complications resulting in unfavorable patient outcomes. Clevidipine emerges in the current drug scenario as an antihypertensive agent with advantageous properties like ultra-short half-life, titratable effect, and ease of use. Methods: A systematic search of PubMed/MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Google Scholar databases was performed aided by a specific search string, to provide a synthesis of the available body of literature regarding clevidipine administration for the management of hypertension in the perioperative cardiac and noncardiac surgical settings. Results: Eighteen documents (summarizing data from 2,066 patients) published between 1997 and 2023 were included in the present review. Clevidipine was extensively compared to both placebo and other commonly used antihypertensive medications. Discussion: Clevidipine demonstrated favorable efficacy and promising safety profiles. Moreover, it may represent a promising aid for the intraoperative management of hypertension, and a valuable addition to traditional antihypertensive drugs. However, significant gaps in research still persist, and further studies are warranted to better dissect its effects in frail populations and patients of different ethnicities. Systematic review protocol: PROSPERO (CRD42024568584).
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Bottussi et al. (2025) conducted a systematic review in Perioperative hypertension (n=2,066). Clevidipine vs. Placebo or other antihypertensive medications was evaluated on Blood pressure control and safety. Clevidipine demonstrated favorable efficacy and promising safety profiles for the intraoperative management of hypertension in cardiac and noncardiac surgical settings.
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