Key result
Clevidipine significantly reduced the rate of treatment failure for preoperative hypertension compared to placebo (7.5% vs 82.7%; P < 0.0001) in patients scheduled for cardiac surgery.
Why the study?
Does clevidipine infusion rapidly reduce preoperative blood pressure in patients scheduled for cardiac surgery with hypertension?
Population
105 patients scheduled for cardiac surgery with preoperative hypertension
Comparison
Clevidipine IV infusion for at least 30 min vs 20% lipid emulsion IV infusion for at least 30 min
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
at least 30 min
Authors
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Clevidipine may be prioritized for preoperative hypertension before cardiac surgery; confirms efficacy versus placebo in RCT.
RCT (n=105)
Double-blind
randomized
Yes
Does clevidipine infusion rapidly reduce preoperative blood pressure in patients scheduled for cardiac surgery with hypertension?
Absolute Event Rate: 7.5% vs 82.7%
p-value: p=< 0.0001
Clevidipine is highly effective and rapid at reducing preoperative blood pressure in patients undergoing cardiac surgery.
Levy et al. (2007) conducted an RCT in Preoperative hypertension in cardiac surgery (n=105). Clevidipine vs. 20% lipid emulsion (placebo) was evaluated on Treatment failure (failure to reduce SBP by ≥15% from baseline or discontinuance of drug for any reason) (p=< 0.0001). Clevidipine significantly reduced the rate of treatment failure for preoperative hypertension compared to placebo (7.5% vs 82.7%; P < 0.0001) in patients scheduled for cardiac surgery.
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