What question did this study set out to answer?

This study aims to evaluate the relationships between myocyte necrosis and fibrosis in renovascular hypertensive rats.

September 1, 1997Brazilian Journal of Medical and Biological ResearchOpen Access

Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats

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Why the study?

Does renovascular hypertension induce myocardial fibrosis and alter myocardial function in male Wistar rats?

Population

Male Wistar rats

Comparison

Unilateral renal ischemia evaluated at week 4… vs Normotensive control rats

Design

Preclinical

Follow-up

8 weeks

Authors

MOMarina Politi OkoshiUniversidade Estadual Paulista (Unesp)LML.S. MatsubaraChallenger Learning Center of Alaska MFM. FrancoUniversidade Federal de Santa Maria

Discussion

Member takes

Implication

Supports necrosis-driven fibrosis in renovascular hypertension models; leaves open translation to human hypertensive heart disease.

Key Points

This study aims to evaluate the relationships between myocyte necrosis and fibrosis in renovascular hypertensive rats.
Male Wistar rats with unilateral renal ischemia were analyzed at 4 and 8 weeks post-surgery.
Myocardial function was assessed using isolated papillary muscles and morphological features were examined through light microscopy.
Myocardial hydroxyproline concentration was measured to evaluate fibrosis.
Systolic arterial pressure was significantly elevated in RHT rats compared to controls (RHT4: 178 +/- 19 mmHg, RHT8: 194 +/- 24 mmHg, P < 0.05).
Myocardial hydroxyproline concentration increased significantly in the RHT8 group (3.44 +/- 0.45 micrograms/mg, P < 0.05 vs control).
Myocyte necrosis and vascular damage were observed, leading to reparative fibrosis and increased myocardial stiffness in the RHT rat groups.

Structured PICO

Does renovascular hypertension induce myocardial fibrosis and alter myocardial function in male Wistar rats?

Population

Male Wistar rats

Intervention

Unilateral renal ischemia (Goldblatt II hypertension model) evaluated at week 4 (RHT4) and week 8 (RHT8)

Comparator

Normotensive control rats

Outcome

Myocardial function (isolated papillary muscle preparations), morphological features (light microscopy), and myocardial hydroxyproline concentration (HOP)surrogate

In a rat model of renovascular hypertension, reparative fibrosis occurs as a consequence of myocyte and arteriole necrosis rather than just pressure overload.

Cite This Study

Okoshi et al. (1997) studied this question.

synapsesocial.com/papers/6a71e374e5469ee92be22e11 https://doi.org/10.1590/s0100-879x1997000900013

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Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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