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Does lidocaine reduce ventricular arrhythmias and mortality in experimental myocardial infarction?
Does lidocaine reduce ventricular arrhythmias and mortality in experimental myocardial infarction?
High-dose lidocaine reduces mortality and ventricular arrhythmias in experimental myocardial infarction, potentially by correcting myocardial electrolyte abnormalities.
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High-dose lidocaine may reduce mortality and arrhythmias in experimental MI; leaves open clinical translation.
Ventricular arrhythmias and mortality of acute experimental myocardial infarction were associated with myocardial K+ loss, Na+ gain, and water accumulation. Lidocaine at low doses was unable to correct arrhythmia or myocardial K+ loss. A high dose of lidocaine was effective in reducing mortality and arrhythmia, and an associated improvement in the electrolyte abnormality was seen.
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Asokan et al. (1972) studied this question.
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