Why the study?
Does type II diabetes mellitus alter the pharmacokinetics and pharmacodynamics of amlodipine in hypertensive patients?
Population
28 hypertensive patients, including 18 with type II diabetes mellitus and 10 nondiabetic hypertensive patients
Comparison
Amlodipine 5 mg or 10 mg administered over a… vs Nondiabetic hypertensive patients receiving the…
Design
Cohort
Follow-up
6 weeks
Authors
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No PK differences seen in this cohort; leaves open whether diabetes affects amlodipine response in larger prospective studies.
Does type II diabetes mellitus alter the pharmacokinetics and pharmacodynamics of amlodipine in hypertensive patients?
The presence of type II diabetes mellitus does not significantly alter the pharmacokinetics or pharmacodynamics of amlodipine in hypertensive patients.
Preston et al. (2001) studied this question.
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