Why the study?
Does Trypanosoma cruzi infection cause morphologic alterations in the vagus nerve in a rat model of Chagas' disease?
Population
Male Wistar rats weighing 90-110 g (n=36; 6 per group per time point)
Comparison
Intraperitoneal injection of 1.0 ml of infected… vs Intraperitoneal injection of an equal inoculum…
Design
Preclinical
Follow-up
Up to 185 days (evaluated at 7, 50, and 185 days)
Authors
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Vagal myelin changes may contribute to autonomic dysfunction in Chagas disease; hypothesis-generating for human studies.
Does Trypanosoma cruzi infection cause morphologic alterations in the vagus nerve in a rat model of Chagas' disease?
Experimental Chagas' disease in rats causes transient myelin damage and axonal swelling in the vagus nerve during the acute phase, which may contribute to the pathogenesis of cardiac and digestive autonomic alterations.
Fazan et al. (1997) studied this question.
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