Key result
Chronic Trypanosoma cruzi infection in rats impaired cardiac parasympathetic function, reducing the baroreflex bradycardia index compared to controls (-0.51% vs -0.64%; p<0.05).
Why the study?
Does chronic Trypanosoma cruzi infection impair cardiac parasympathetic function and cause neuroganglionitis in a rat model?
Population
90 male Wistar rats
Comparison
Chronic Trypanosoma cruzi infection vs Age and sex matched non-infected controls
Design
Preclinical
Follow-up
8 months
Authors
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Provides rat model of T. cruzi autonomic impairment; leaves open translation to human Chagas disease.
Does chronic Trypanosoma cruzi infection impair cardiac parasympathetic function and cause neuroganglionitis in a rat model?
Absolute Event Rate: -0.51% vs -0.64%
p-value: p=<0.05
Chronic Trypanosoma cruzi infection in rats induces cardiac autonomic dysfunction and neuroganglionitis, providing an animal model that mimics the parasympathetic impairment seen in human Chagas' disease.
Junqueira et al. (1992) studied Chronic Chagas' disease (n=90). Trypanosoma cruzi infection vs. Non-infected controls was evaluated on Relative index between maximum heart rate decrease and maximum systolic blood pressure increase (baroreflex bradycardia) (p=<0.05). Chronic Trypanosoma cruzi infection in rats impaired cardiac parasympathetic function, reducing the baroreflex bradycardia index compared to controls (-0.51% vs -0.64%; p<0.05).
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