Why the study?
Does autonomic nervous system modulation affect the inflammatory immune response and parasite clearance in mice with acute Chagas disease?
Population
Mice inoculated with Trypanosoma cruzi (wild-type and vesicular acetylcholine transporter knockdown C57BL/6j…
Comparison
Autonomic nervous system modulation via genetic… vs Negative control groups matched for age, genetic…
Design
Preclinical
Follow-up
18-21 days
Authors
Loading...
May influence acute Chagas progression in mice; leaves open human translation and therapeutic relevance.
Does autonomic nervous system modulation affect the inflammatory immune response and parasite clearance in mice with acute Chagas disease?
The autonomic nervous system plays a marked immunomodulatory role in acute Chagas heart disease, inhibiting inflammatory responses and parasite clearance.
Machado et al. (2012) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: