Key result
Coxsackie virus A9 (CVA9) was identified as the primary pathogen responsible for a large outbreak of aseptic meningitis, accounting for 60.5% of typed outbreak cases, with two distinct co-circulating lineages.
Why the study?
An unusually high number of paediatric aseptic meningitis cases with detected human enterovirus occurred at a hospital in Mossel Bay, South Africa, prompting an outbreak investigation.
Observational (n=63)
No
Coxsackie virus A9 was identified as the primary pathogen responsible for a large outbreak of aseptic meningitis in South Africa, highlighting the importance of molecular surveillance.
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Alerts clinicians to CVA9 in aseptic meningitis outbreaks; extends enterovirus surveillance data but remains hypothesis-generating.
Smuts et al. (2018) conducted an observational in Aseptic meningitis (n=63). Coxsackie virus A9 (CVA9) infection was evaluated on Proportion of typed outbreak cases caused by Coxsackie virus A9 (CVA9). Coxsackie virus A9 (CVA9) was identified as the primary pathogen responsible for a large outbreak of aseptic meningitis, accounting for 60.5% of typed outbreak cases, with two distinct co-circulating lineages.
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