Key result
The 2010 outbreak of aseptic meningitis in Alberta was predominantly associated with enterovirus CVA-9, accounting for 81.94% of sequenced isolates, which exhibited genetic drifting and recombination.
Population
4323 clinical samples submitted for enterovirus testing in Alberta, Canada in 2010, of which 213 were…
Authors
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Warrants vigilance for evolving enterovirus strains in aseptic meningitis; leaves open the role of herd immunity in outbreak emergence.
Observational (n=4,323)
The 2010 aseptic meningitis outbreak in Alberta was driven by a CVA-9 strain that evolved via genetic drift and recombination but retained conserved antigenic regions, suggesting a decline in herd immunity rather than a novel immune escape mutant.
Pabbaraju et al. (2013) conducted an observational in Aseptic meningitis (n=4,323). Coxsackie A9 virus was evaluated on Proportion of enterovirus positive samples typed as CVA-9. The 2010 outbreak of aseptic meningitis in Alberta was predominantly associated with enterovirus CVA-9, accounting for 81.94% of sequenced isolates, which exhibited genetic drifting and recombination.
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