Key result
Most hypertensive patients with positive case detection for primary aldosteronism also had positive results on the captopril challenge and furosemide upright tests (86% and 87%, respectively).
Why the study?
Are confirmatory tests always needed in hypertensive patients with positive case detection for primary aldosteronism?
Population
120 hypertensive patients with positive case detection for primary aldosteronism using the aldosterone to…
Design
Cohort
Authors
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Supports selective omission of confirmatory testing after positive case detection; leaves open need for prospective validation before practice change.
Observational (n=120)
Are confirmatory tests always needed in hypertensive patients with positive case detection for primary aldosteronism?
p-value: p=<0.01
Confirmatory testing for primary aldosteronism may not be necessary in all patients with positive case detection, particularly those with ARR ≥1000 or PAC ≥250 pg/ml.
Nanba et al. (2012) conducted an observational in Primary aldosteronism (n=120). Confirmatory testing (captopril challenge, furosemide upright, or saline infusion tests) was evaluated on Percentage of patients with positive confirmatory test results (p=<0.01). Most hypertensive patients with positive case detection for primary aldosteronism also had positive results on the captopril challenge and furosemide upright tests (86% and 87%, respectively).
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