What question did this study set out to answer?

To establish a reproducible canine model of acute Stanford type B aortic dissection using an optimized surgical approach and a custom pressure-driven flow device.

December 4, 2022EXPERIMENTAL ANIMALSOpen Access

Construction of a canine model with acute type B aortic dissection using a self-made pressure-driven flow device

Q: What is the clinical evidence from this study?

Population: Stanford type B aortic dissection (n=18). Intervention: Surgical construction of TBAD using a self-made pressure-water flow device. Primary outcome: Success rate of the modeling operation.

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Key result

A novel surgical method using a self-made pressure-water flow device successfully constructed a reproducible canine model of Stanford type B aortic dissection with an 88.8% success rate.

Why the study?

A reproducible canine aortic dissection model would be useful for evaluating the performance of novel endovascular treatment devices.

Population

18 dogs

Comparison

Creation of Stanford type B aortic dissection using a surgical method and pressure-driven flow device

Design

Animal model development study

Follow-up

10 d

Authors

ZLZongwei LiuTsinghua University JBJiaxue BiTianjin Medical University General Hospital FNFang NiuUniversity of Electronic Science and Technology of China

Discussion

Member takes

Implication

May accelerate preclinical TBAD device testing; clinical translation remains untested.

Key Points

To establish a reproducible canine model of acute Stanford type B aortic dissection using an optimized surgical approach and a custom pressure-driven flow device.
Aortic dissection was surgically induced in dogs (N=18) using a novel self-made pressure-driven flow device to lengthen the false lumen.
Computed tomography angiography was performed at 2 hours post-procedure, followed by digital subtraction angiography, intravascular ultrasound (IVUS), and color Doppler flow imaging (CDFI) at 10 days.
Model construction was successful in 88.8% of dogs (16/18), with all 16 surviving dogs developing distal re-entries (mean 1.50 ± 0.52) and a mean false lumen length of 175.37 ± 16.98 mm.
IVUS demonstrated that the false lumen occupied 84.88 ± 1.27% of the arterial area at the narrowest segment.
CDFI showed disordered flow in the false lumen with peak systolic velocity significantly lower than in the true lumen (10.89 ± 0.74 cm/s vs. 25.31 ± 1.72 cm/s; P<0.001).

Structured PICO

Population

18 healthy adult mongrel dogs, aged 12-24 months and weighing 15-20 kg, underwent a surgical procedure to construct a Stanford type B aortic dissection model and were followed for 10 days.

Intervention

Surgical construction of a Stanford type B aortic dissection (TBAD) model using a self-made pressure-water flow device.

Outcome

Success rate of model construction (defined as successful awakening, separation of true and false lumens via CTA at 2 hours, and persistent false lumen via ultrasound at 10 days).surrogate

A novel surgical method using a pressure-water flow device successfully created a reproducible canine model of type B aortic dissection with an 88.8% success rate, providing a platform for evaluating endovascular devices.

Limitations

The false lumen was constructed from the tunica adventitia to the tunica intima, which differs from the natural pathophysiology in human patients.
The location of the distal re-entry could not be controlled and was governed by chance and pressured water hemodynamics.
Distal re-entries did not extend beyond the celiac trunk artery, unlike in many real-world patients where they involve main abdominal or iliac branches.
False lumen constructed from tunica adventitia to tunica intima, unlike real-world patients
Did not control the construction of a re-entry at the distal end
Re-entries did not exceed the celiac trunk artery

Cite This Study

Liu et al. (2022) studied Stanford type B aortic dissection (n=18). Surgical construction of TBAD using a self-made pressure-water flow device was evaluated on Success rate of the modeling operation. A novel surgical method using a self-made pressure-water flow device successfully constructed a reproducible canine model of Stanford type B aortic dissection with an 88.8% success rate.

synapsesocial.com/papers/6a71e779e5469ee92be23037 https://doi.org/10.1538/expanim.22-0073

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Construction of a canine model with acute type B aortic dissection using a self-made pressure-driven flow device

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Construction of a canine model with acute type B aortic dissection using a self-made pressure-driven flow device

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider