A Network Analysis to Compare Biomarker Profiles in Patients with and without Diabetes Mellitus in Acute Heart Failure
Why the study?
Do biomarker profiles and network correlations differ between acute heart failure patients with and without diabetes mellitus?
Population
2,033 patients with acute heart failure enrolled in the PROTECT trial, including 922 with diabetes and 1,111…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Does not alter AHF care in diabetes; hypothesis-generating for interconnected remodelling-inflammation pathways pending prospective validation.
Structured PICO
Do biomarker profiles and network correlations differ between acute heart failure patients with and without diabetes mellitus?
P
Population
2,033 patients with acute heart failure (AHF) enrolled in the PROTECT trial, including 922 with diabetes and 1,111 without diabetes.
C
Comparator
Patients without diabetes (n=1,111)
O
Outcome
Differences in levels of 48 circulating biomarkers measured within 24 hours of admission and their network correlationssurrogate
Patients with acute heart failure and diabetes exhibit distinct biomarker profiles and network correlations compared to those without diabetes, suggesting different underlying pathophysiological processes.
Cite This Study
Sharma et al. (2017) studied this question.