March 1, 1998Biochemical JournalOpen Access

Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration

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Why the study?

Does Angeli's salt stimulate human neutrophil migration via intracellular conversion to nitric oxide?

Structured PICO

Does Angeli's salt stimulate human neutrophil migration via intracellular conversion to nitric oxide?

Population

Human neutrophils

Intervention

Angeli's salt (AS) (nitroxyl anion donor)

Comparator

Gaseous nitric oxide (.NO) and various inhibitors/scavengers (methionine, metHb, L-cysteine, soluble guanylate cyclase inhibitor, cGMP-dependent protein kinase antagonists)

Outcome

Neutrophil migrationsurrogate

Angeli's salt stimulates human neutrophil migration partly through intracellular conversion of nitroxyl anion to nitric oxide and subsequent cGMP signaling.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Findings remain preclinical and should not alter practice; leaves open nitroxyl's role in human neutrophil function.

Cite This Study

VanUFFELEN et al. (1998) studied this question.

synapsesocial.com/papers/6a71ec2231a3df824329df4b https://doi.org/10.1042/bj3300719

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Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration

Structured PICO

Discussion

Implication

Cite This Study

Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider